Query: NC_010682:3745000 Ralstonia pickettii 12J chromosome 1, complete sequence Lineage: Ralstonia pickettii; Ralstonia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: Ralstonia pickettii 12J was isolated from copper-contaminated sediment from a lake in Michigan, USA. In addition to being highly resistant to copper, strain 12J is also resistant to zinc and cadmium. Ralstonia pickettii can be isolated from a wide range of environmental and clinical samples. This species is a nocosomial pathogen. It is associated with infections caused by contaminated solutions, such as distilled water and intravenous solutions. Ralstonia pickettii strains resistant to heavy metals have also been isolated from heavy metal contaminated environments.
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General Information: This type strain came from a Chinese patient in Burma who had glanders in 1944. Causes glanders in horses. This organism is rarely associated with human infection, and is more commonly seen in domesticated animals such as horses, donkeys, and mules where it causes glanders, a disease first described by Aristotle. The pathogen is host-adapted and is not found in the environment outside of its host. Rapid-onset pneumonia, bacteremia (spread of the organism through the blood), pustules, and death are common outcomes during infection. No vaccine exists for this potentially dangerous organism.