Pre_GI: SWBIT SVG BLASTN

Query: NC_010556:462500 Exiguobacterium sibiricum 255-15, complete genome

Lineage: Exiguobacterium sibiricum; Exiguobacterium; Bacillales Family XII; Bacillales; Firmicutes; Bacteria

General Information: This organism was isolated from a 2-3 million-year permafrost core in Siberia, Russia and can survive and grow rapidly at low temperatures. Analysis of long-term survival of psychrophilic organisms such as this one may aid understanding of the potential growth of organisms in astrobiology. Exiguobacterium sibiricum is a psychrotolerant organism able to grow at temperatures that range from -6 to 40 degrees C. This organism is also able to survive repeated freeze/thaw cycles which may contribute to its ability to survive in cold environments.

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BLASTN Alignment.txt

Subject: NC_004557:1 Clostridium tetani E88, complete genome

Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.