Pre_GI: SWBIT SVG BLASTN

Query: NC_010263:167450 Rickettsia rickettsii str. Iowa, complete genome

Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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BLASTN Alignment.txt

Subject: NC_015722:462450 Candidatus Midichloria mitochondrii IricVA chromosome, complete

Lineage: Midichloria mitochondrii; Midichloria; Candidatus Midichloriaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Candidatus Midichloria mitochondrii is a symbiont of the tick Ixodes ricinus. The importance of this organism is two-fold. this symbiont is the only bacterium described that is able of invading the mitochondria of animals. The host Ixodes ricinus is a vector of a number of human diseases.