Pre_GI: SWBIT SVG BLASTN

Query: NC_010263:167450 Rickettsia rickettsii str. Iowa, complete genome

Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

- Sequence; - BLASTN hit (Low score = Light, High score = Dark)
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BLASTN Alignment.txt

Subject: NC_013716:4728500 Citrobacter rodentium ICC168, complete genome

Lineage: Citrobacter rodentium; Citrobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia in mice. This disease is characterized by a hyperproliferation of the epithelial cells in the colon similar to that found in humans suffering from idiopathic inflammatory bowel disease. In addition this organism contains virulence factors similar to those found in enterohemorrhagic Escherichia coli and enteropathogenic E. coli. C. rodentium are being used as models for studying mucosal response to infection, colon tumor production, and virulence associated with pathogenic E. coli.