Query: NC_010168:1373337 Renibacterium salmoninarum ATCC 33209 chromosome, complete genome Lineage: Renibacterium salmoninarum; Renibacterium; Micrococcaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This bacterial pathogen is the causal agent of bacterial kidney disease (BKD) of salmonid fish. This disease is a significant threat to the healthy and sustainable production of salmon for consumption and species conservation efforts in the USA. The development of treatments are further complicated as the organism is vertically transmitted from infected females to their eggs, is difficult to culture in vitro, and is a facultative intracellular pathogen. The completion of the genome sequence of Renibacterium salmoninarum will be a benefit to the scientific community at many levels and will be of immediate use to researchers and fish health practitioners dealing with BKD in farmed fish as well as captive broodstocks of endangered species-listed populations. For example, genome data will serve as a foundation for identification of virulence factors, DNA vaccine gene candidates, and improved diagnostic tests.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: This strain (genotype F11) represents the largest portion of isolates recovered from tuberculosis patients during a TB epidemic in the Western Cape of South Africa. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.