Pre_GI: SWBIT SVG BLASTN

Query: NC_010162:573709 Sorangium cellulosum 'So ce 56', complete genome

Lineage: Sorangium cellulosum; Sorangium; Polyangiaceae; Myxococcales; Proteobacteria; Bacteria

General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.

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BLASTN Alignment.txt

Subject: NC_020134:2832857 Clostridium stercorarium subsp. stercorarium DSM 8532, complete

Lineage: Clostridium stercorarium; Clostridium; unclassified Ruminococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: Lignocellulosic biomass has great potential as an abundant and renewable source of fermentable sugars through enzymic saccharification. Clostridium stercorarium is a catabolically versatile bacterium producing a wide range of hydrolases for degradation of biomass. Together with Clostridium thermocellum, Clostridium aldrichii and other cellulose degraders, it forms group I of the clostridia. It is moderately thermophilic, with an optimum growth temperature of 65 degrees C, and has repeatedly been isolated from self-heated compost. The two-component cellulase system of C. stercorarium has been investigated thoroughly. Due to its ability to utilize the various polysaccharides present in biomass it is especially suited for the fermentation of hemicellulose to organic solvents. Some isolates have been used in Japan in a single-step ethanol-fermenting pilot-process with lignocellulosic biomass as substrate.