Query: NC_010162:573709 Sorangium cellulosum 'So ce 56', complete genome Lineage: Sorangium cellulosum; Sorangium; Polyangiaceae; Myxococcales; Proteobacteria; Bacteria General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.
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General Information: Phytopathogen that causes bacterial wilt and canker of tomato (Lycopersicon esculentum). This is considered to be the most important bacterial disease of tomato causing substantial economic losses worldwide. Bacteria enter the plant by wounds on root or stem and then find their way into the xylem allowing a massive systemic colonization. The first stage of the disease is characterized by unilateral wilting of leaves. Wilting then spreads to all leaves, canker lesions develop on the stem and the plant dies. If infection occurs at a late stage of plant development, plants can survive and yield fruit that may have spots, so called bird's eyes. Often the seeds will be infected and this has been the major source for outbreaks of Clavibacter michiganensis subsp. michiganensis infections in agriculture. Members of the Clavibacter genus are known to produce antimicrobial compounds.