Pre_GI: SWBIT SVG BLASTN

Query: NC_010162:573709 Sorangium cellulosum 'So ce 56', complete genome

Lineage: Sorangium cellulosum; Sorangium; Polyangiaceae; Myxococcales; Proteobacteria; Bacteria

General Information: Sorangium cellulosum 'So ce 56' produces a large number of bioactive compounds, such as, the antifungal soraphen and the anticancer agent epothilone. This organism, like other myxobacteria, undergoes a complex development and differentiation pathway. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100 000 cells. The motility system is not dependent on flagella like most bacteria, but instead relies on twitching pili: short extracellular appendages that may function analogously to oars in a rowboat. The myxobacteria have proved to be a rich source of novel natural products. Sorangium cellulosum produces a number of antibacterial, antifungal and cytotoxic substances which are being studies for therapeutic applications.

Subject: NC_010376:186510 Finegoldia magna ATCC 29328, complete genome

Lineage: Finegoldia magna; Finegoldia; Clostridiales Family XI; Clostridiales; Firmicutes; Bacteria

General Information: It is isolated most frequently from various infection sites, including soft tissue, bone and joint, and diabetic foot infections. This species, formerly Peptostreptococcus magnus, is a commensal bacterium colonizing human skin and mucous membranes. It has been shown to cause valve endocarditic in humans. Gram-positive anaerobic cocci (GPAC) are a major part of the normal human flora colonizing skin and mucous membranes of the mouth and gastrointestinal tracts. In GPAC, Finegoldia magna (formerly Peptostreptococcus magnus) has the highest pathogenicity and is isolated most frequently from various infection sites, including soft tissue, bone and joint, and diabetic foot infections.