Pre_GI: SWBIT SVG BLASTN

Query: NC_010120:609323 Neisseria meningitidis 053442, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_008228:2295841 Pseudoalteromonas atlantica T6c, complete genome

Lineage: Pseudoalteromonas atlantica; Pseudoalteromonas; Pseudoalteromonadaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: Isolated from a biofilm from San Diego Bay in California. Marine biofilm bacterium associated with shell disease in shellfish. A common marine bacterium that exists both in the water column, and in biofilms attached to surfaces. This organism produces a well characterized, commercially important agarase. Pseudoalteromonas atlantica has been isolated from lesions on crabs with shell disease. Shell disease is characterized by progressive degradation of the shell, often leading to an infection of the hemolymph (blood) and may be caused by Pseudoalteromonas, Alteromonas, Vibrio, or other marine organisms. In addition to producing extracellular enzymes which attack the shell, Pseudoalteromonas atlantica produces a the lipopolysaccharide which has been shown to be a potential virulence factor in shell disease.