Pre_GI: SWBIT SVG BLASTN

Query: NC_009831:1255995 Shewanella sediminis HAW-EB3, complete genome

Lineage: Shewanella sediminis; Shewanella; Shewanellaceae; Alteromonadales; Proteobacteria; Bacteria

General Information: Shewanella sediminis was isolated from sediment taken at a depth of 215 meters from an unexploded-ordinance-dumping site 50 nautical miles from Halifax Harbor, Canada in the Atlantic Ocean. This organism is able to degrade hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) anaerobically at 10 degrees C. RDX is a member of a family of nitramine compounds which are used in the production of explosives. Shewanella are facultatively anaerobic, Gram-negative bacteria, motile by polar flagella, rod-like, and generally associated with aquatic or marine environments.

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BLASTN Alignment.txt

Subject: NC_002971:1523065 Coxiella burnetii RSA 493, complete genome

Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.