Pre_GI: SWBIT SVG BLASTN

Query: NC_009785:387910 Streptococcus gordonii str. Challis substr. CH1, complete genome

Lineage: Streptococcus gordonii; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: Normal human oral flora. Most streptococci are facultative anaerobes, and some are obligate anaerobes. Serologic grouping is based on antigenic differences in cell wall carbohydrates, in cell wall pili-associated protein, and in the polysaccharide capsule in group B streptococci. Streptococcus gordonii is a commensal member of the human oral flora. It initiates the formation of biofilms on tooth surfaces known as dental plaque, which is strongly associated with the development of dental cavities (caries) and gum disease. It is a frequent causative agent of bacterial endocarditis (inflammation of the membrane lining the heart) which often occurs as a result of oral trauma, allowing S. gordonii to invade the bloodstream and colonize the heart.

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BLASTN Alignment.txt

Subject: NC_009009:2286000 Streptococcus sanguinis SK36, complete genome

Lineage: Streptococcus sanguinis; Streptococcus; Streptococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain was isolated from human dental plaque in 1980 and is virulent in a rat model. Indigenous oral bacteria that causes dental decay and possibly endocarditis. Most streptococci are facultative anaerobes, and some are obligate anaerobes. Serologic grouping is based on antigenic differences in cell wall carbohydrates, in cell wall pili-associated protein, and in the polysaccharide capsule in group B streptococci. This microbe is found associated with human oral bacterial communities and can colonize the dental surfaces, aiding other organisms in attachment. Progression of caries and periodontal disease are associated with this microbe as is endocarditis which can lead to death.