Pre_GI: SWBIT SVG BLASTN

Query: NC_009697:3711692 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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BLASTN Alignment.txt

Subject: NC_012589:1917421 Sulfolobus islandicus L.S.2.15, complete genome

Lineage: Sulfolobus islandicus; Sulfolobus; Sulfolobaceae; Sulfolobales; Crenarchaeota; Archaea

General Information: Sulfolobus islandicus L.S.2.15 (Lassen #1) was isolated from Lassen National Park in California, USA. Hyperthermophilic acidophilic sulfur-metabolizing archeon. Sulfolobus islandicus is a thermo-acidophilic archeae commonly identified in hot, acidic sulfur springs. This organism can grow both chemoautotrophically, using sulfur or hydrogen sulfide, and heterotrophically. S. islandicus can play host to a number of plasmids and viruses which may be useful in developing tools for genetic analysis. In addition, Sulfolobus islandicus isolates from different areas in Russia, Iceland, and the United States have been shown to be genetically distinct from each other making this organism useful for comparative analysis.