Query: NC_009515:510121 Methanobrevibacter smithii ATCC 35061, complete genome Lineage: Methanobrevibacter smithii; Methanobrevibacter; Methanobacteriaceae; Methanobacteriales; Euryarchaeota; Archaea General Information: Methanobrevibacter smithii ATCC 35061 (DSM 861) (strain PS) was isolated from a sewage digester in Gainesville, Florida, USA. Sewage digester isolate. Human gut methanogen. Methanobrevibacter smithii can be isolated from anoxic environments such as anaerobic digesters, anaerobic soil and sediment, and the gastrointestinal tracts of humans, ruminants and other animals. This organism is the dominant archaeal symbiont found in the human gut.
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General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.