Query: NC_009505:264963 Brucella ovis ATCC 25840 chromosome I, complete sequence Lineage: Brucella ovis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: This strain was isolated from sheep tissue in Australia. Causes brucellosis in sheep. This organism specifically affects sheep, causing ovine brucellosis which results in significant economic losses. Infection by the organism can cause infertility in rams as the bacterium preferentially colonizes the genital tract, and causes inflammation of the epididymis which leads to necrotic lesions and a decrease in sperm numbers and motility. This bacterium, like other Brucella, is an intracellular pathogen that infects phagocytic cells such as macrophages. Bacterial cells produces a lipopolysaccharide that lacks O-antigen side chains, which results in a rough colony phenotype, and aids in differentiation as compared to other Brucella.
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General Information: This strain was isolated prior to 1985 and belongs to the antiqua biovar. It can ferment rhamnonse and melibiose which is a property usually associated with Yersinia pseudotuberculosis. Strain Angola belongs to a group of atypical Yersinia pestis strains with genotypic similarities that are intermediate between Y. pestis and Y. pseudotuberuclosis strains. Genotypic studies indicate that strain Angola is the oldest Y. pestis strain analyzed to date. It carries three plasmids that are similar to other Y. pestis plasmids but have aberrant sizes. The critical virulence factor, the V antigen, is different than that encoded by typical strains of Y. pestis and there is a deletion that affects the F1 operon. Strain Angola has been shown to be virulent by aerosol in mice.