Query: NC_009505:264963 Brucella ovis ATCC 25840 chromosome I, complete sequence Lineage: Brucella ovis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: This strain was isolated from sheep tissue in Australia. Causes brucellosis in sheep. This organism specifically affects sheep, causing ovine brucellosis which results in significant economic losses. Infection by the organism can cause infertility in rams as the bacterium preferentially colonizes the genital tract, and causes inflammation of the epididymis which leads to necrotic lesions and a decrease in sperm numbers and motility. This bacterium, like other Brucella, is an intracellular pathogen that infects phagocytic cells such as macrophages. Bacterial cells produces a lipopolysaccharide that lacks O-antigen side chains, which results in a rough colony phenotype, and aids in differentiation as compared to other Brucella.
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General Information: Industrially important bacterium. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism is a soil-dwelling endospore-forming microbe similar to other Bacilli. This bacterium is used extensively in the industrial production of important enzymes such as proteases, penicllinases, and amylases as well as smaller compounds like the antibiotic bacitracin and various organic metabolites. This organism is closely related to Bacillus subtilis on the basis of rRNA typing, and it has been found to occasionally cause illness in humans.