Pre_GI: SWBIT SVG BLASTN

Query: NC_009381:1783886 Yersinia pestis Pestoides F chromosome, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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BLASTN Alignment.txt

Subject: NC_014623:7482229 Stigmatella aurantiaca DW4/3-1 chromosome, complete genome

Lineage: Stigmatella aurantiaca; Stigmatella; Cystobacteraceae; Myxococcales; Proteobacteria; Bacteria

General Information: Social gliding soil bacterium. Stigmatella aurantica, commonly isolated from rotting wood and bark, is a member of a group of organisms called myxobacteria. These organisms have a complex development and differentiation life cycle. When cell density increases, the organism switches to "social motility" where aggregates of cells can gather together into masses termed fruiting bodies that may consist of up to 100,000 cells. Stigmatella aurantica produces a number of compounds, such as aurafuron A and stigmatellin, which may be important as anti-cancer agents.