Query: NC_009328:2161116 Geobacillus thermodenitrificans NG80-2 chromosome, complete genome Lineage: Geobacillus thermodenitrificans; Geobacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: Geobacillus thermodenitrificans NG80-2 was isolated from oil reservoir formation water taken at a depth of 2000 m and a temperature of 73 degrees C. This strain can use crude oil as a sole carbon source and can degrade 16 to 36 carbon alkanes. Geobacillus thermodenitrificans NG80-2 produces an emulsifier which may be useful for high temperature biodegradation or other industrial purposes. Members of this genus were originally classified as Bacillus. Recent rDNA analysis and DNA-DNA hybridization studies using spore-forming thermophilic subsurface isolates provided enough evidence to define the phylogenetically distinct, physiologically and morphologically consistent taxon Geobacillus. Geobacillus species are chemo-organotrophic, obligately thermophilic, motile, spore-forming, aerobic or facultatively anaerobic.
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General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.