Query: NC_009256:1365500 Burkholderia vietnamiensis G4 chromosome 1, complete sequence Lineage: Burkholderia vietnamiensis; Burkholderia; Burkholderiaceae; Burkholderiales; Proteobacteria; Bacteria General Information: B. vietnamiensis strain G4 (formerly B.cepacia strain R1808) is the best trichloroethene (TCE) co-oxidizing strain yet discovered, having been isolated from an industrial waste treatment facility at Pensacola Naval Air Station, Florida, U.S.A. Burkholderia vietnamiensis is a member of the Burkholderia cepacia complex which contains a number of closely related Burkholderia species. Burkholderia vietnamiensis is commonly isolated from soil and water and has been studied as a plant growth promoting bacterium and as a bioremediation agent for aromatic hydrocarbons such as benzene and tolulene.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.