Query: NC_009142:5459819 Saccharopolyspora erythraea NRRL 2338, complete genome Lineage: Saccharopolyspora erythraea; Saccharopolyspora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Source of the antibiotic erythromycin. Saccharopolyspora erythraea is the soil bacterium that produces the industrially important antibiotic erythromycin A. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: The strain was isolated from a symbiotic association with the gymnosperm cycad Macrozamia sp. It typically grows in freshwater habitats. This genera of cyanobacteria are typically terrestrially-associated and are especially found in limestone or nutrient-poor soils. They are very similar to Anabaena spp. and historically they have been distinguished on the basis of morphological and life cycle characteristics. Nostoc spp. can grow heterotrophically or photoheterotrophically, and form heterocysts for nitrogen fixation. This organism can form nitrogen-fixing symbiotic relationships with plants and fungi such as the bryophyte Anthoceros punctatus. The relationship is relatively simple as compared to the Rhizobial symbiotic relationship. In the presence of the plant, hormogonia (short motile filaments) infect the plant, and then form long heterocyst-containing (nitrogen-fixing differentiated bacterial cells) filaments. The bacterial cell receives carbon sources in exchange for fixed nitrogen.