Pre_GI: SWBIT SVG BLASTN

Query: NC_008769:3242453 Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome

Lineage: Mycobacterium bovis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This organism was used to produce the antigen which was utilized for vaccine development. Causative agent of classic bovine tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of classic bovine tuberculosis, but it can also cause the disease in humans, especially if contaminated milk is consumed without prior pasteurization. The Mycobacterium bovis complex is a diverse group of species, serovars and morphotypes that cause tuberculosis-like diseases in animals and humans. Pasteurization of milk is a major preventitive factor in transmission of bovine tuberculosis to humans. However, spreading the disease through milk and dairy products is still a concern in underdeveloped countries where pasteurization is not practiced.

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BLASTN Alignment.txt

Subject: NC_008611:2615204 Mycobacterium ulcerans Agy99, complete genome

Lineage: Mycobacterium ulcerans; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This organism causes Buruli ulcer and is the third most common mycobacterial pathogen after Mycobacterium tuberculosis and Mycobacterium leprae. The disease has increased dramatically through central and West Africa since the late 1980s. Causative agent of Buruli and Bairnsdale ulcer. Infection by Mycobacterium ulcerans causes the formation of skin ulcers which, if left untreated, can lead to extensive scarring and/or amputation. Mycobacterium ulcerans produces a cytotoxin, mycolactone, which causes the destruction of skin tissue seen in this disease. This organism is resistant to antibiotics and treatment involves the surgical removal of infected tissues.