Pre_GI: SWBIT SVG BLASTN

Query: NC_008767:927810 Neisseria meningitidis FAM18, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

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BLASTN Alignment.txt

Subject: NC_015947:2231493 Burkholderia sp. JV3 chromosome, complete genome

Lineage: Stenotrophomonas maltophilia; Stenotrophomonas; Xanthomonadaceae; Xanthomonadales; Proteobacteria; Bacteria

General Information: Environment: Rhizosphere, Host, Rhizosphere-colonizing; Temp: Mesophile. This species is an uncommon but serious source of infection in patients with breathing tubes such as endotracheal or tracheostomy tubes, or with chronically indwelling urinary catheters. Although the organism can colonize the devices without causing an infection, under certain conditions it can cause pneumonia, urinary tract infections, or an infection of the blood. This organism can also cause infection in immunocompromised patients. It has resistance to many commonly used antibiotics and therefore is often difficult to eradicate. Most strains are resistant to co-trimoxazole.