Query: NC_008554:4839116 Syntrophobacter fumaroxidans MPOB, complete genome Lineage: Syntrophobacter fumaroxidans; Syntrophobacter; Syntrophobacteraceae; Syntrophobacterales; Proteobacteria; Bacteria General Information: This organism is a syntrophic propionate-oxidizing bacterium isolated from granular sludge from an anaerobic sludge bed reactor treating sugar-beet processing wastewater. Propionate-oxidizing bacterium. This organism is able to oxidize propionate when grown in co-culture with hydrogen-consuming methanogens (syntrophic metabolism). This organism can also ferment fumarate when not in co-culture.
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General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.