Query: NC_008554:3177723 Syntrophobacter fumaroxidans MPOB, complete genome Lineage: Syntrophobacter fumaroxidans; Syntrophobacter; Syntrophobacteraceae; Syntrophobacterales; Proteobacteria; Bacteria General Information: This organism is a syntrophic propionate-oxidizing bacterium isolated from granular sludge from an anaerobic sludge bed reactor treating sugar-beet processing wastewater. Propionate-oxidizing bacterium. This organism is able to oxidize propionate when grown in co-culture with hydrogen-consuming methanogens (syntrophic metabolism). This organism can also ferment fumarate when not in co-culture.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.