Pre_GI: SWBIT SVG BLASTN

Query: NC_008261:2614817 Clostridium perfringens ATCC 13124, complete genome

Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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BLASTN Alignment.txt

Subject: NC_004344:622318 Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,

Lineage: Wigglesworthia glossinidia; Wigglesworthia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism is the obligate endosymbiont for the tsetse fly Glossina brevipalpis. As Wigglesworthia brevipalpis resides intracellularly, the resulting co-evolution with its host over millions of years has led to a drastic reduction in the bacterium's genome size, resulting in this its inability to survive outside the host. Tsetse fly endosymbiont. This organism is the obligate endosymbiont for the tsetse fly Glossina brevipalpis, Glossina tachinoides, Glossina palpalis palpalis, and Glossina austeni. The tsetse fly is a vector for African trypanosomes, and is the main transmitter of deadly diseases in animals and humans in Africa. The fly feeds on a restricted diet, exclusively consisting of vertebrate blood, and lacks certain metabolic compounds needed for survival and reproduction. To complement this lack in nutrients, the tsetse fly relies mainly on the intracellular bacterial symbiont, Wigglesworthia glossinidia for its viability and fecundity.