Pre_GI: SWBIT SVG BLASTN

Query: NC_008260:2340824 Alcanivorax borkumensis SK2, complete genome

Lineage: Alcanivorax borkumensis; Alcanivorax; Alcanivoracaceae; Oceanospirillales; Proteobacteria; Bacteria

General Information: This bacterium was isolated from a seawater sediment sample in the North Sea. The species is able to use Mihagol-S (C14,15-n-alkanes) as a principal carbon source. Using n-alkanes as a sole carbon source causes the strains to produce extracellular and membrane-bound surface-active glucose lipids. Phenotypic analysis showed a restricted nutritional profile, high halotolerance, the absence of fermentative metabolism, and a low G+C content. This, in combination with a 16S phylogenetic study, allowed the placing of this organism into a new genus.

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BLASTN Alignment.txt

Subject: NC_004741:2741971 Shigella flexneri 2a str. 2457T, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.