Pre_GI: SWBIT SVG BLASTN

Query: NC_008258:1076922 Shigella flexneri 5 str. 8401, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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BLASTN Alignment.txt

Subject: NC_013416:1429881 Aggregatibacter actinomycetemcomitans D11S-1, complete genome

Lineage: Aggregatibacter actinomycetemcomitans; Aggregatibacter; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: Aggregatibacter actinomycetemcomitans D11S-1 was recovered from a subject with aggressive periodontitis. Aggregatibacter actinomycetemcomitans, previously Actinobacillus actinomycetemcomitans typically resides in the oral cavity of humans and animals and can cause a number of diseases. The bacterium, along with 3 other organisms, is the main culprit in periodontis, which results in devastation to the bone supporting the teeth. Adherence to oral surfaces is controlled through the tad (tight adherence) locus, which may express proteins that are involved in type IV secretion.