Query: NC_007964:717590 Nitrobacter hamburgensis X14, complete genome Lineage: Nitrobacter hamburgensis; Nitrobacter; Bradyrhizobiaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Nitrobacter hamburgensis X14 was isolated from soil. Nitrite-oxidizing soil bacterium. Members of this genus are found in marine, freshwater, and terrestrial habitats, often in association with ammonia-oxidizing bacteria. These organisms oxidize nitrite, generated by the oxidation of ammonia, to nitrate and play an important role in the global nitrogen cycle. The enzyme involved in nitrite oxidation, nitrite oxidoreductase, can also reduce nitrate to nitrite in the absence of oxygen, allowing Nitrobacter sp. to grow anaerobically. Nitrobacter hamburgensis is commonly isolated from freshwater, soil, and sewage sludge. This organism has been used in biofilms to remove nitrogen from wastewater.
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General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.