Query: NC_007799:968499 Ehrlichia chaffeensis str. Arkansas, complete genome Lineage: Ehrlichia chaffeensis; Ehrlichia; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria General Information: This strain is the first isolate of Ehrlichia chaffeensis, which was obtained from a patient on an army base in Arkansas, USA in 1990. Causes disease in humans. This organism is an obligate intracellular pathogen that exists within vacuoles in the cytoplasm of monocytes or granulocytes. Transferred during an insect (tick) bite, it can cause disease in humans (human monocytic ehrlichiosis) and can reside in several other animals and is a problem in immunocompromised patients. The bacterium inhibits phagosome-lysozome fusion as well as programmed cell death (apoptosis) of the host cell, similar to what is observed with Anaplasma phagocytophilum.
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General Information: Normal oral and gastrointestinal bacterium. This genus contains mostly obligately anaerobic bacilli. Many of the isolates are spindle-shaped, or fusiform. This organism belongs to the normal microflora of the human oral and gastrointestinal tracts. It is a very long and slender spindle-shaped bacillus with sharply pointed ends that is characterized by the ability to invade soft tissues. It acts as a bridge between early and late colonizers of the tooth surface, and exerts synergism with other bacteria in mixed infections. It is most frequently associated with periodontal diseases, as well as with some invasive human infections of the head and neck, chest, lung, liver and abdomen, and some anginas. One of the major amino acid and sugar fermentation pathways in Fusobacterium nucleatum produces butyric and acetic acids.