Query: NC_007181:1094422 Sulfolobus acidocaldarius DSM 639, complete genome Lineage: Sulfolobus acidocaldarius; Sulfolobus; Sulfolobaceae; Sulfolobales; Crenarchaeota; Archaea General Information: Sulfolobus acidocaldarius DSM 639 was isolated from and acidic hot spring in Yellowstone National Park. Extreme thermoacidophilic sulfur-oxidizing archaeon. This organsim is an extreme thermoacidophilic, sulfur-oxidizing archaeon commonly found in hot springs growing at very high temperatures. This obligate aerobe is immotile and grows at a temperature of 55-85 degrees C with optimal growth at 70-75 degrees C. The pH for growth is 1-6 with an optimum pH 2-3.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.