Query: NC_006142:33268 Rickettsia typhi str. Wilmington, complete genome Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.
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General Information: This species was isolated from tissue cultures of Populus, the Poplar tree. Colonies are pink to red, and the red pigment is water insoluble. Species of the genus Methylobacterium are strictly aerobic, facultatively methylotrophic, Gram-negative, rod-shaped bacteria that are able to grow on one-carbon compounds (e.g. methanol or methylamine), as well as on a variety of C2, C3 and C4 substrates. Only the type species, Methylobacterium organophilum, has been shown to use methane as the sole source of carbon and energy. Members of the genus are distributed in a wide variety of natural and man-made environments, including soil, air, dust, fresh- and marine water and sediments, water supplies, bathrooms, air-conditioning systems and masonry, and some are opportunistic human pathogens.