Query: NC_006142:33268 Rickettsia typhi str. Wilmington, complete genome

Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

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BLASTN Alignment.txt

Subject: NC_010556:691498 Exiguobacterium sibiricum 255-15, complete genome

Lineage: Exiguobacterium sibiricum; Exiguobacterium; Bacillales Family XII; Bacillales; Firmicutes; Bacteria

General Information: This organism was isolated from a 2-3 million-year permafrost core in Siberia, Russia and can survive and grow rapidly at low temperatures. Analysis of long-term survival of psychrophilic organisms such as this one may aid understanding of the potential growth of organisms in astrobiology. Exiguobacterium sibiricum is a psychrotolerant organism able to grow at temperatures that range from -6 to 40 degrees C. This organism is also able to survive repeated freeze/thaw cycles which may contribute to its ability to survive in cold environments.