Pre_GI: SWBIT SVG BLASTN

Query: NC_004917:946550 Helicobacter hepaticus ATCC 51449, complete genome

Lineage: Helicobacter hepaticus; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This organism was found to be linked to an increasing incidence of liver tumors in mouse colonies at the National Cancer Institute in 1992. Normally it resides in the lower intestines, but it can cause chronic hepatitis. This organism has a similar urease gene cluster and cytolethal distending toxin as compared to Helicobacter pylori, but lacks other virulence factors such as the vacuolating cytotoxin and the cag pathogenicity island. However, it does contain a pathogenicity island that encodes proteins similar to those found in a type IV secretion system. Causes liver disease. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). This species was associated with an increase in liver tumors. It can cause active chronic hepatitis and typhlitis (inflammation of a region at the beginning of the large intestine), hepatocellular tumors, and gastric bowel disease in various mice strains.

- Sequence; - BLASTN hit (Low score = Light, High score = Dark)
- hypothetical protein; - cds: hover for description

BLASTN Alignment.txt

Subject: NC_008043:167108 Silicibacter sp. TM1040 mega plasmid, complete sequence

Lineage: Ruegeria; Ruegeria; Rhodobacteraceae; Rhodobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from a culture of the dinoflagellate Pfiesteria piscicida CCMP1830 which has been implicated in many large scale algal blooms resulting in increased mortality in fish. The bacteria are attached to the surface of the dinoflagellate and in some ways allow the dinoflagellate to grow as those lacking the bacteria die off. The bacterium also chemotaxes towards the dinoflagellate product DMSP (dimethylsulfoniopropionate) and metabolizes it. DMSP is a major source of sulfur in marine ecosystems and plays a role in the sulfur biogeochemical cycle. The implication is a tight association between these important dinoflagellates and this marine bacterium.