Query: NC_004757:2451919 Nitrosomonas europaea ATCC 19718, complete genome Lineage: Nitrosomonas europaea; Nitrosomonas; Nitrosomonadaceae; Nitrosomonadales; Proteobacteria; Bacteria General Information: Ammonia-oxidizing bacterium. This organism is an obligate chemo-lithoautotroph as it only uses ammonia and carbon dioxide and mineral salts for growth, and is an important part of the global biogeochemical nitrogen cycle. It can derive all energy requirements from the oxidation of ammonia to nitrate, driving global nitrogen from the reduced insoluble form to the oxidized and potentially gaseous form (including NO and NO2 which are greenhouse gases). The energy derived from ammonia oxidation is in turn used to drive carbon fixation. This bacterium also provides plants with a readily available form of nitrogen, is important in wastewater treatment, and may be involved in bioremediation of sites contaminated with toxic compounds.
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General Information: This strain was isolated from a patient in 1994. Opportunistic pathogen that causes multiple hospital-acquired infections. This organism is the most medically important organism within the genus Klebsiella. It is an environmental organism found in water, soil, and on the surface of plants. Several strains have been isolated from plant tissues and are nitrogen-fixing endophytes that may be a source of nitrogen for the plant. Other strains can become opportunistic pathogens which infect humans, and typically causes hospital-acquired infections in immunocompromised patients. Major sites of infection include the lungs, where it causes a type of pneumonia, and urinary tract infections. Klebsiella can also enter the bloodstream (bacterimia) and cause sepsis. The pathogen can also infect animals and cause inflammation of the uterus in horses as well as more generalized infections in other mammals. This organism expresses numerous pathogenicity factors, including multiple adhesins, capsular polysaccharide, siderophores, and lipopolysaccharide for the evasion of host defenses. The multiple antibiotic resistance genes carried on the chromosome inhibit efforts to clear the organism from infected patients via antibiotic use.