Pre_GI: SWBIT SVG BLASTN

Query: NC_004310:1578918 Brucella suis 1330 chromosome I, complete sequence

Lineage: Brucella suis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: A swine isolate. Causes brucellosis, infectious abortions, fevers. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a swine-specific Brucella. It causes infectious abortions in animals and a systemic, febrile (feverish) illness in humans. Brucella suis is considered a potential bioterrorism agent and was the first pathogenic organism to be weaponized by the USA.

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BLASTN Alignment.txt

Subject: NC_012026:75812 Anaplasma marginale str. Florida, complete genome

Lineage: Anaplasma marginale; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Anaplasma marginale str. Florida. was isolated from pooled blood samples from naturally infected cattle in Florida. The Florida strain is virulent and non-tick transmitted. This organism is the causative agent of bovine anaplasmosis and is an obligate intracellular pathogen. Transmission occurs via an arthropod vector (tick) and is a major problem in tropical regions where it causes severe morbidity in cattle populations. The bacterium lives intracellularly within membrane-bound vesicles in the host erythrocyte, a cell type which it specifically targets, resulting in severe anemia for the host organism.