Pre_GI: SWBIT SVG BLASTN

Query: NC_004310:1578918 Brucella suis 1330 chromosome I, complete sequence

Lineage: Brucella suis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: A swine isolate. Causes brucellosis, infectious abortions, fevers. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a swine-specific Brucella. It causes infectious abortions in animals and a systemic, febrile (feverish) illness in humans. Brucella suis is considered a potential bioterrorism agent and was the first pathogenic organism to be weaponized by the USA.

Subject: NC_011852:211314 Haemophilus parasuis SH0165, complete genome

Lineage: Haemophilus parasuis; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: This organism is the causative agent of Glasser's disease in swine but is usually found as a commensal organism in the upper respiratory tract. Glasser's disease is responsible for significant losses in swine husbandry. The disease was first noted in 1910 by Glasser and the organism requires factor V (NAD - nicotinamide adenine dinucleotide) growth factor, like H. suis, but not factor X (iron porphyrin) which H. suis requires. Pathogenicity and virulence are often strain specific. Symptoms include fibrinous polyserositis (fibrous inflammation of serous membranes, polyarthritis (inflammation of multiple joints) and meningitis (inflammation of meninges)and pneumonia.