Pre_GI: SWBIT SVG BLASTN

Query: NC_003997:674265 Bacillus anthracis str. Ames, complete genome

Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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BLASTN Alignment.txt

Subject: NC_009848:161373 Bacillus pumilus SAFR-032, complete genome

Lineage: Bacillus pumilus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Bacillus pumilus SAFR-032 was isolated from the Spacecraft Assembly Facility at NASA Jet Propulsion Laboratory, USA and produces spores highly resistant to UV radiation. A ubiquitous soil organism. Bacillus pumilus is a naturally occurring, ubiquitous soil microorganism. Commonly found in a variety of food commodities, some strains have developed an increased tolerance to gamma irradiation. This bacterium colonizes the root zone of some plants, where it inhibits soil-borne fungal diseases and nematodes. It is also undergoing evaluation for commercial production of cellulase, an enzyme used for conversion of cellulolytic materials to soluble sugars or solvents.