Query: NC_003919:3060484 Xanthomonas axonopodis pv. citri str. 306, complete genome Lineage: Xanthomonas citri; Xanthomonas; Xanthomonadaceae; Xanthomonadales; Proteobacteria; Bacteria General Information: This organism is the causal agent of citrus canker, a bacterial infection originating from southeast Asia which now occurs worldwide. Primarily a pathogen of plants in the Citrus genus, the disease is sometimes also found in other members of the Rutaceae. The bacterium survives in leaf, shoot and fruit lesions that develop during the spring, and which also cause secondary infections. During warm, wet weather in spring and early summer, the bacterium oozes out of overwintering lesions and infects new growth via the stomal pores or wounds. The bacterium may also survive for various periods of time in the soil or associated with other hosts.
- Sequence; - BLASTN hit (Low score = Light, High score = Dark) - hypothetical protein; - cds: hover for description
General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.