Query: NC_003911:3453764 Silicibacter pomeroyi DSS-3, complete genome Lineage: Ruegeria pomeroyi; Ruegeria; Rhodobacteraceae; Rhodobacterales; Proteobacteria; Bacteria General Information: Formerly Silicibacter pomeroyi, his marine bacterium is a member of the Roseobacter clade and was isolated off of the coast of Georgia in 1998. Dimethylsulfoniopropionate-degrading bacterium. Capable of degrading the organic sulfur compound DMSP (dimethylsulfoniopropionate) and can metabolize a number of sulfur compounds. DMSP is synthesized by marine algae and the degradation product dimethylsulfide contributes to the global sulfur cycle.
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General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.