Pre_GI: SWBIT SVG BLASTN

Query: NC_003103:266013 Rickettsia conorii str. Malish 7, complete genome

Lineage: Rickettsia conorii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from a human in South Africa. Causative agent for Rocky Mountain spotted fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes Rocky Mountain spotted fever which can cause severe damage to the endothelial layer of major organs, including the lungs, heart, kidneys, and skeletal muscle which can result in death.

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BLASTN Alignment.txt

Subject: NC_008343:823093 Granulibacter bethesdensis CGDNIH1, complete genome

Lineage: Granulibacter bethesdensis; Granulibacter; Acetobacteraceae; Rhodospirillales; Proteobacteria; Bacteria

General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.