Pre_GI: SWBIT SVG BLASTN

Query: NC_002940:1065246 Haemophilus ducreyi 35000HP, complete genome

Lineage: Haemophilus ducreyi; Haemophilus; Pasteurellaceae; Pasteurellales; Proteobacteria; Bacteria

General Information: This strain is a human passage derivative of Haemophilus ducreyi strain 35000 that is serum-resistant. Causative agent of chancroid. A group of organisms that are either obligate parasites or commensal organisms found in animal mucous membranes. Almost all species require the presence of important growth factors found in the blood of their hosts, including either X factor (protoporphyrin IX or heme) or V factor (nicotinamide adenine dinucleotide (NAD or NADP)). This organism is an obligate human pathogen that causes the sexually transmitted disease chancroid (ulcer of the genital region) and it enhances the transmission of HIV (which enhances Haemophilus ducreyi transmission in turn). This organism is an apparent extracellular pathogen that resists phagocytosis. Some of the virulence factors include an outer membrane serum resistance protein, as well as two toxins, cytolethal distending toxin (CDT) and hemolysin, both of which contribute to tissue destruction.

Subject: NC_014121:4299500 Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, complete

Lineage: Enterobacter cloacae; Enterobacter; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Enterobacter species are found in natural environments such as water, sewage, soil, and vegetables; some species are found in human and animal species. Enterobacter cloacae is a prevalent nosocomial pathogen as it is highly resistant to disinfectants and antimicrobial agents. E.cloacae subsp. cloacae strain ATCC 13047 was isolated from human cerebrospinal fluid in 1890 and is the type strain. These "ICU bugs" cause significant morbidity and mortality, and infection management is complicated by multiple antibiotic resistance. These bacteria possess inducible beta-lactamases, which are undetectable in vitro but are also responsible for resistance during treatment.