Query: NC_002932:296557 Chlorobium tepidum TLS, complete genome Lineage: Chlorobaculum tepidum; Chlorobaculum; Chlorobiaceae; Chlorobiales; Chlorobi; Bacteria General Information: This green-sulfur bacterium is a thermophile and was isolated from a New Zealand high-sulfide hot spring. Photosynthetic thermophile. Chlorobium tepidum is a member of the green-sulfur bacteria. It has been suggested that the green-sulfur bacteria were among the first photosynthetic organisms since they are anaerobically photosynthetic and may have arisen early in the Earth's history when there was a limited amount of oxygen present. This organism utilizes a novel photosynthetic system, and harvests light energy using an unusual organelle, the chlorosome, which contains an aggregate of light-harvesting centers surrounded by a protein-stabilized galactolipid monolayer that lies at the inner surface of the cytoplasmic membrane. Unlike many other photosynthetic organisms, the green-sulfur bacteria do not produce oxygen and tolerate only low levels of the molecule. This organism also fixes carbon dioxide via a reverse tricarboxylic acid cycle, using electrons derived from hydrogen or reduced sulfur to drive the reaction, instead of via the Calvin cycle like many other photosynthetic organisms.
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General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.