Query: NC_002678:2739829 Mesorhizobium loti MAFF303099, complete genome Lineage: Mesorhizobium loti; Mesorhizobium; Phyllobacteriaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Plant symbiont bacterium. This organism contains a symbiosis island that is responsible for symbiotic relationships with plants (lotus) which is similar to what is observed with other Rhizobia that form similar relationships with legumes. The bacterium enters root nodules and performs nitrogen-fixation for the plant cell while being provided with a protective environment to grow in. Nitrogen fixation and root nodule formation genes are carried on a symbiosis island.
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General Information: This strain was isolated from an infected goat and is pathogenic in humans. Causes brucellosis and undulant fever. They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.