Pre_GI: OUP MCL Sub Cluster Neighbours

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Query: NC_015571:1495286 Porphyromonas gingivalis TDC60, complete genome

D: 35.0012

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host DescriptionProposed Island FlowSubject Island D
NC_002950:1748582*Porphyromonas gingivalis W83, complete genomeSubject ←→ Query33.0466
NC_010729:1818500*Porphyromonas gingivalis ATCC 33277, complete genomeSubject ←→ Query34.844
NC_015571:1495286*Porphyromonas gingivalis TDC60, complete genomeSubject ←→ Query35.0012
NC_002950:353549*Porphyromonas gingivalis W83, complete genomeSubject ←→ Query37.9482
NC_010729:265791*Porphyromonas gingivalis ATCC 33277, complete genomeSubject ←→ Query37.9921
NC_015571:440605*Porphyromonas gingivalis TDC60, complete genomeSubject ←→ Query38.2669
NC_002950:155873*Porphyromonas gingivalis W83, complete genomeSubject ←→ Query38.7123