Pre_GI: OUP Neighbours

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Query: NC_011896:3252925 Mycobacterium leprae Br4923, complete genome

D: 27.6905

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

Number of Neighbours: 3

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_005027:4180502*Rhodopirellula baltica SH 1, complete genome75.4841 %Subject ←→ Query26.8786
NC_011896:1*Mycobacterium leprae Br4923, complete genome78.6918 %Subject ←→ Query32.6217
NC_002677:1*Mycobacterium leprae TN, complete genome78.6336 %Subject ←→ Query32.6702