Pre_GI: OUP Neighbours

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Query: NC_011528:1769349 Coxiella burnetii CbuK_Q154, complete genome

D: 24.6589

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

Number of Neighbours: 92

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_009727:1001203*Coxiella burnetii Dugway 7E9-12, complete genome79.1299 %Subject ←→ Query21.1029
NC_011527:953442*Coxiella burnetii CbuG_Q212, complete genome79.0319 %Subject ←→ Query21.4555
NC_009727:766000*Coxiella burnetii Dugway 7E9-12, complete genome77.6593 %Subject ←→ Query21.7504
NC_003210:403743Listeria monocytogenes EGD-e, complete genome75.6219 %Subject ←→ Query22.1607
NC_003210:2879906*Listeria monocytogenes EGD-e, complete genome76.5135 %Subject ←→ Query22.1972
NC_011527:1113217Coxiella burnetii CbuG_Q212, complete genome76.8627 %Subject ←→ Query22.3158
NC_011528:767940*Coxiella burnetii CbuK_Q154, complete genome78.8848 %Subject ←→ Query22.4009
NC_009727:1542000*Coxiella burnetii Dugway 7E9-12, complete genome79.4761 %Subject ←→ Query22.7322
NC_015697:116000*Lactobacillus reuteri SD2112 chromosome, complete genome75.6955 %Subject ←→ Query22.793
NC_010117:980313Coxiella burnetii RSA 331, complete genome76.8689 %Subject ←→ Query22.8964
NC_002971:780502Coxiella burnetii RSA 493, complete genome79.0809 %Subject ←→ Query23.0652
NC_009727:1177390Coxiella burnetii Dugway 7E9-12, complete genome80.1899 %Subject ←→ Query23.0788
NC_011527:1443076*Coxiella burnetii CbuG_Q212, complete genome77.595 %Subject ←→ Query23.1396
NC_011528:647401Coxiella burnetii CbuK_Q154, complete genome78.4283 %Subject ←→ Query23.1688
NC_006300:1624254*Mannheimia succiniciproducens MBEL55E, complete genome80.6281 %Subject ←→ Query23.223
NC_011527:1255998Coxiella burnetii CbuG_Q212, complete genome75.1256 %Subject ←→ Query23.804
NC_011528:1282691*Coxiella burnetii CbuK_Q154, complete genome77.7635 %Subject ←→ Query23.9948
NC_009727:357206*Coxiella burnetii Dugway 7E9-12, complete genome87.8676 %Subject ←→ Query24.1054
NC_009053:313779Actinobacillus pleuropneumoniae L20, complete genome76.3388 %Subject ←→ Query24.5075
NC_006300:1140635Mannheimia succiniciproducens MBEL55E, complete genome76.633 %Subject ←→ Query24.5104
NC_011026:1181940Chloroherpeton thalassium ATCC 35110, complete genome77.9933 %Subject ←→ Query24.8017
NC_002971:1545924*Coxiella burnetii RSA 493, complete genome94.807 %Subject ←→ Query24.9297
NC_010117:1633447*Coxiella burnetii RSA 331, complete genome96.2102 %Subject ←→ Query25.1409
NC_015660:3643370Geobacillus thermoglucosidasius C56-YS93 chromosome, complete75.6771 %Subject ←→ Query25.9515
NC_006300:600516Mannheimia succiniciproducens MBEL55E, complete genome78.9645 %Subject ←→ Query26.1215
NC_010939:321492Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete75.9528 %Subject ←→ Query26.1819
NC_012913:280506Aggregatibacter aphrophilus NJ8700, complete genome79.5098 %Subject ←→ Query26.6691
NC_010939:1986263*Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete75.2237 %Subject ←→ Query26.8824
NC_008526:1973500Lactobacillus casei ATCC 334, complete genome75.337 %Subject ←→ Query27.286
NC_012913:2189862*Aggregatibacter aphrophilus NJ8700, complete genome77.1446 %Subject ←→ Query27.2935
NC_015660:1076159Geobacillus thermoglucosidasius C56-YS93 chromosome, complete77.693 %Subject ←→ Query27.3103
NC_015731:2400526*Nitrosomonas sp. Is79A3 chromosome, complete genome75.3401 %Subject ←→ Query27.4684
NC_016023:729843Bacillus coagulans 36D1 chromosome, complete genome76.4828 %Subject ←→ Query27.5069
NC_009053:553298*Actinobacillus pleuropneumoniae L20, complete genome78.8082 %Subject ←→ Query27.7268
NC_015222:1905194*Nitrosomonas sp. AL212 chromosome, complete genome75.7721 %Subject ←→ Query27.742
NC_015222:1843093Nitrosomonas sp. AL212 chromosome, complete genome75.098 %Subject ←→ Query27.7777
NC_015660:2685842Geobacillus thermoglucosidasius C56-YS93 chromosome, complete76.3756 %Subject ←→ Query28.0392
NC_012793:383612*Geobacillus sp. WCH70, complete genome77.4234 %Subject ←→ Query28.1218
NC_010939:1809446*Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete77.595 %Subject ←→ Query28.1766
NC_013416:820989*Aggregatibacter actinomycetemcomitans D11S-1, complete genome78.1526 %Subject ←→ Query28.2199
NC_012793:3275751*Geobacillus sp. WCH70, complete genome78.2721 %Subject ←→ Query28.4508
NC_010939:405477*Actinobacillus pleuropneumoniae serovar 7 str. AP76, complete77.2304 %Subject ←→ Query28.4796
NC_012913:1832500*Aggregatibacter aphrophilus NJ8700, complete genome76.4491 %Subject ←→ Query28.5015
NC_009053:895965Actinobacillus pleuropneumoniae L20, complete genome77.7482 %Subject ←→ Query28.5832
NC_015660:1988000Geobacillus thermoglucosidasius C56-YS93 chromosome, complete77.3621 %Subject ←→ Query28.8303
NC_015660:391627*Geobacillus thermoglucosidasius C56-YS93 chromosome, complete78.1189 %Subject ←→ Query28.9358
NC_015660:3467579*Geobacillus thermoglucosidasius C56-YS93 chromosome, complete77.4112 %Subject ←→ Query28.9622
NC_015660:3518931Geobacillus thermoglucosidasius C56-YS93 chromosome, complete76.5227 %Subject ←→ Query29.0471
NC_015222:1607757Nitrosomonas sp. AL212 chromosome, complete genome75.9957 %Subject ←→ Query29.1095
NC_009053:1785447*Actinobacillus pleuropneumoniae L20, complete genome76.7279 %Subject ←→ Query29.5139
NC_011026:1284966*Chloroherpeton thalassium ATCC 35110, complete genome77.2763 %Subject ←→ Query29.7452
NC_007514:335085*Chlorobium chlorochromatii CaD3, complete genome75.3676 %Subject ←→ Query29.799
NC_010999:623489Lactobacillus casei, complete genome75.1072 %Subject ←→ Query29.8391
NC_010554:1008444Proteus mirabilis HI4320, complete genome75.6556 %Subject ←→ Query29.9611
NC_009053:1081651Actinobacillus pleuropneumoniae L20, complete genome76.5993 %Subject ←→ Query30.6172
NC_015660:296488Geobacillus thermoglucosidasius C56-YS93 chromosome, complete75.5116 %Subject ←→ Query31.3239
NC_010999:1381497*Lactobacillus casei, complete genome75.3983 %Subject ←→ Query31.3851
NC_013416:1621469Aggregatibacter actinomycetemcomitans D11S-1, complete genome78.2874 %Subject ←→ Query31.4418
NC_015703:1992000*Runella slithyformis DSM 19594 chromosome, complete genome75.1256 %Subject ←→ Query31.5564
NC_011026:3009500*Chloroherpeton thalassium ATCC 35110, complete genome78.6979 %Subject ←→ Query31.8736
NC_011026:2533017*Chloroherpeton thalassium ATCC 35110, complete genome78.9154 %Subject ←→ Query31.9226
NC_011026:2450325Chloroherpeton thalassium ATCC 35110, complete genome76.2837 %Subject ←→ Query32.4678
NC_006582:4256915*Bacillus clausii KSM-K16, complete genome75.337 %Subject ←→ Query32.4815
NC_014551:865254Bacillus amyloliquefaciens DSM 7, complete genome76.1795 %Subject ←→ Query32.6062
NC_015634:2779392Bacillus coagulans 2-6 chromosome, complete genome75.6036 %Subject ←→ Query32.7639
NC_013895:605488*Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, complete76.829 %Subject ←→ Query32.8408
NC_012914:1923500Paenibacillus sp. JDR-2, complete genome78.2292 %Subject ←→ Query33.2254
NC_012914:5194791Paenibacillus sp. JDR-2, complete genome77.7145 %Subject ←→ Query33.2273
NC_015277:5211779*Sphingobacterium sp. 21 chromosome, complete genome75.7598 %Subject ←→ Query33.2563
NC_016023:2265000Bacillus coagulans 36D1 chromosome, complete genome77.0466 %Subject ←→ Query33.3949
NC_015581:680460Thioalkalimicrobium cyclicum ALM1 chromosome, complete genome76.3664 %Subject ←→ Query33.4619
NC_011026:2269986*Chloroherpeton thalassium ATCC 35110, complete genome80.337 %Subject ←→ Query33.5605
NC_013199:2058857*Lactobacillus rhamnosus Lc 705, complete genome75.383 %Subject ←→ Query33.7873
NC_016023:2163000*Bacillus coagulans 36D1 chromosome, complete genome75.2206 %Subject ←→ Query34.5001
NC_015634:2547144Bacillus coagulans 2-6 chromosome, complete genome75.0674 %Subject ←→ Query34.5737
NC_013198:2088780*Lactobacillus rhamnosus GG, complete genome76.152 %Subject Query35.0489
NC_015634:959396Bacillus coagulans 2-6 chromosome, complete genome76.152 %Subject Query35.0988
NC_015277:689519*Sphingobacterium sp. 21 chromosome, complete genome76.9118 %Subject Query35.7416
NC_015634:3017564*Bacillus coagulans 2-6 chromosome, complete genome75.3952 %Subject Query35.8382
NC_006322:567987*Bacillus licheniformis ATCC 14580, complete genome77.0956 %Subject Query35.8713
NC_015634:2595500Bacillus coagulans 2-6 chromosome, complete genome75.049 %Subject Query35.9909
NC_006510:3321426Geobacillus kaustophilus HTA426, complete genome76.1183 %Subject Query36.1711
NC_014551:605855Bacillus amyloliquefaciens DSM 7, complete genome75.2849 %Subject Query36.6948
NC_006322:203932*Bacillus licheniformis ATCC 14580, complete genome77.7941 %Subject Query37.4168
NC_015572:1252000Methylomonas methanica MC09 chromosome, complete genome75.7384 %Subject Query38.7541
NC_015277:3351504*Sphingobacterium sp. 21 chromosome, complete genome75.4994 %Subject Query38.8988
NC_012914:5618000Paenibacillus sp. JDR-2, complete genome76.2316 %Subject Query39.6612
NC_006510:591339Geobacillus kaustophilus HTA426, complete genome77.2886 %Subject Query42.2291
NC_006510:3133965*Geobacillus kaustophilus HTA426, complete genome75.9651 %Subject Query43.1524
NC_006905:4638707*Salmonella enterica subsp. enterica serovar Choleraesuis str77.4112 %Subject Query45.4121
NC_004547:1174650*Erwinia carotovora subsp. atroseptica SCRI1043, complete genome75.6771 %Subject Query48.0379
NC_012880:3421500*Dickeya dadantii Ech703, complete genome76.6238 %Subject Query54.2571