Query: NC_011527:525759 Coxiella burnetii CbuG_Q212, complete genome
D: 24.8054
Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria
General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.
Number of Neighbours: 21
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Subject Host Description |
Compositional Similarity |
Proposed Island Flow | Subject Island D |
---|
NC_011528:535680* | Coxiella burnetii CbuK_Q154, complete genome | 95.4779 % | Subject ←→ Query | 24.6535 |
NC_002971:1379567* | Coxiella burnetii RSA 493, complete genome | 94.1238 % | Subject ←→ Query | 25.3769 |
NC_010117:1461502* | Coxiella burnetii RSA 331, complete genome | 93.7255 % | Subject ←→ Query | 25.1338 |
NC_002971:211331* | Coxiella burnetii RSA 493, complete genome | 80.2972 % | Subject ←→ Query | 34.2373 |
NC_013416:1588369 | Aggregatibacter actinomycetemcomitans D11S-1, complete genome | 78.4007 % | Subject ←→ Query | 26.0305 |
NC_011528:386417* | Coxiella burnetii CbuK_Q154, complete genome | 77.598 % | Subject ←→ Query | 30.2955 |
NC_010117:285230* | Coxiella burnetii RSA 331, complete genome | 77.5153 % | Subject ←→ Query | 31.6756 |
NC_013416:1429881* | Aggregatibacter actinomycetemcomitans D11S-1, complete genome | 76.8903 % | Subject ←→ Query | 26.7692 |
NC_002971:1523065* | Coxiella burnetii RSA 493, complete genome | 76.8015 % | Subject ←→ Query | 23.0028 |
NC_015572:1974000* | Methylomonas methanica MC09 chromosome, complete genome | 76.777 % | Subject ←→ Query | 31.2378 |
NC_013416:1526920 | Aggregatibacter actinomycetemcomitans D11S-1, complete genome | 76.7402 % | Subject ←→ Query | 26.3831 |
NC_009446:351042 | Dichelobacter nodosus VCS1703A, complete genome | 76.5502 % | Subject ←→ Query | 28.8728 |
NC_015572:1421782 | Methylomonas methanica MC09 chromosome, complete genome | 76.3909 % | Subject ←→ Query | 34.0502 |
NC_015572:427732* | Methylomonas methanica MC09 chromosome, complete genome | 76.0141 % | Subject ← Query | 39.1241 |
NC_009727:1822877* | Coxiella burnetii Dugway 7E9-12, complete genome | 75.6985 % | Subject ←→ Query | 34.0366 |
NC_011527:1688447* | Coxiella burnetii CbuG_Q212, complete genome | 75.6311 % | Subject ←→ Query | 34.3676 |
NC_006510:372826* | Geobacillus kaustophilus HTA426, complete genome | 75.527 % | Subject ←→ Query | 33.0492 |
NC_014915:2092678 | Geobacillus sp. Y412MC52 chromosome, complete genome | 75.4044 % | Subject ←→ Query | 33.7161 |
NC_006510:2044347 | Geobacillus kaustophilus HTA426, complete genome | 75.3554 % | Subject ← Query | 36.7248 |
NC_009727:1678568* | Coxiella burnetii Dugway 7E9-12, complete genome | 75.2665 % | Subject ←→ Query | 33.3414 |
NC_006510:2110430 | Geobacillus kaustophilus HTA426, complete genome | 75.2237 % | Subject ←→ Query | 29.4869 |