Pre_GI: OUP Neighbours

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Query: NC_011498:1571840 Helicobacter pylori P12, complete genome

D: 19.8717

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

Number of Neighbours: 7

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_000915:53715Helicobacter pylori 26695, complete genome84.2004 %Subject ←→ Query20.2152
NC_011498:1345623*Helicobacter pylori P12, complete genome83.796 %Subject ←→ Query23.322
NC_000921:1343701*Helicobacter pylori J99, complete genome82.1998 %Subject ←→ Query23.6929
NC_000921:1147394Helicobacter pylori J99, complete genome86.1366 %Subject ←→ Query25.3465
NC_008229:118000*Helicobacter acinonychis str. Sheeba, complete genome80.6985 %Subject ←→ Query26.5139
NC_014810:9081Helicobacter felis ATCC 49179, complete genome76.8229 %Subject Query30.1131
NC_015674:1605923Helicobacter bizzozeronii CIII-1, complete genome77.9534 %Subject Query31.6766