Pre_GI: OUP Neighbours

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Query: NC_010161:2155500 Bartonella tribocorum CIP 105476, complete genome

D: 32.5841

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

Number of Neighbours: 18

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_008783:145305Bartonella bacilliformis KC583, complete genome79.2739 %Subject ←→ Query26.0032
NC_008783:177161*Bartonella bacilliformis KC583, complete genome80.4688 %Subject ←→ Query30.6709
NC_012846:2004711*Bartonella grahamii as4aup, complete genome86.5564 %Subject ←→ Query27.95
NC_005956:1648000*Bartonella henselae str. Houston-1, complete genome86.0907 %Subject ←→ Query31.2454
NC_005956:1139342*Bartonella henselae str. Houston-1, complete genome75.6005 %Subject ←→ Query23.553
NC_005955:1284500*Bartonella quintana str. Toulouse, complete genome77.0221 %Subject ←→ Query27.0975
NC_005955:1259393*Bartonella quintana str. Toulouse, complete genome75.1961 %Subject ←→ Query23.094
NC_010161:2548254Bartonella tribocorum CIP 105476, complete genome80.1103 %Subject ←→ Query31.3939
NC_010161:1949637Bartonella tribocorum CIP 105476, complete genome78.8235 %Subject ←→ Query31.1808
NC_010161:1811000*Bartonella tribocorum CIP 105476, complete genome79.0656 %Subject ←→ Query27.9374
NC_010161:1598000*Bartonella tribocorum CIP 105476, complete genome76.7249 %Subject ←→ Query30.262
NC_010161:1324381Bartonella tribocorum CIP 105476, complete genome76.1949 %Subject ←→ Query31.3762
NC_007429:585774*Chlamydia trachomatis A/HAR-13, complete genome75.6863 %Subject ←→ Query24.5136
NC_015744:900000*Chlamydia trachomatis L2c chromosome, complete genome75.098 %Subject ←→ Query27.6386
NC_015408:561987Chlamydophila pecorum E58 chromosome, complete genome76.3726 %Subject ←→ Query26.3011
NC_015276:2804874*Marinomonas mediterranea MMB-1 chromosome, complete genome75.2451 %Subject ←→ Query29.8547
NC_013009:225722*Neorickettsia risticii str. Illinois, complete genome76.8045 %Subject ←→ Query30.3647
NC_013512:126915*Sulfurospirillum deleyianum DSM 6946, complete genome75.6587 %Subject ←→ Query25.149