Pre_GI: OUP Neighbours

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Query: NC_010161:1324381 Bartonella tribocorum CIP 105476, complete genome

D: 31.3762

Host Lineage: Bartonella tribocorum; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: This organism was isolated from the blood of wild rats and from fleas obtained from wild rats. Transmission of these organisms is often through an insect vector. Once in a host, this intracellular pathogen is internalized by an actin-dependent mechanism, and primarily targets endothelial cells, although other cells can be infected. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells. This organism is genetically related to Bartonella elizabethae which was isolated from a case of endocarditis in a human.

Number of Neighbours: 13

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_006368:2684358Legionella pneumophila str. Paris, complete genome75.1746 %Subject ←→ Query23.6352
NC_013512:126915*Sulfurospirillum deleyianum DSM 6946, complete genome75.0337 %Subject ←→ Query25.149
NC_002942:1109618Legionella pneumophila subsp. pneumophila str. Philadelphia 1,77.1844 %Subject ←→ Query25.2542
NC_008783:145305Bartonella bacilliformis KC583, complete genome82.4724 %Subject ←→ Query26.0032
NC_005955:1284500*Bartonella quintana str. Toulouse, complete genome76.5809 %Subject ←→ Query27.0975
NC_012982:2415237Hirschia baltica ATCC 49814, complete genome77.0129 %Subject ←→ Query27.8696
NC_012846:2004711*Bartonella grahamii as4aup, complete genome75.0797 %Subject ←→ Query27.95
NC_015559:3511231Marinomonas posidonica IVIA-Po-181 chromosome, complete genome75.8854 %Subject ←→ Query30.6283
NC_008783:177161*Bartonella bacilliformis KC583, complete genome80.0643 %Subject ←→ Query30.6709
NC_010161:1949637Bartonella tribocorum CIP 105476, complete genome90.5821 %Subject ←→ Query31.1808
NC_010161:2548254Bartonella tribocorum CIP 105476, complete genome88.0024 %Subject ←→ Query31.3939
NC_010161:2155500*Bartonella tribocorum CIP 105476, complete genome76.1949 %Subject ←→ Query32.5841
NC_009654:4716417Marinomonas sp. MWYL1, complete genome76.7279 %Subject ←→ Query32.6103