Pre_GI: OUP Neighbours

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Query: NC_008150:3711953 Yersinia pestis Antiqua, complete genome

D: 29.7483

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

Number of Neighbours: 14




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_012962:1661683Photorhabdus asymbiotica, complete genome77.6164 %Subject Query40.4188
NC_012962:3568046Photorhabdus asymbiotica, complete genome77.2396 %Subject ←→ Query37.813
NC_015224:279037Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,77.2243 %Subject ←→ Query28.7938
NC_008150:2599661Yersinia pestis Antiqua, complete genome77.356 %Subject ←→ Query29.7787
NC_003143:2778494Yersinia pestis CO92, complete genome77.0251 %Subject ←→ Query30.2293
NC_004088:266543Yersinia pestis KIM, complete genome75.1624 %Subject ←→ Query30.0081
NC_008149:4053363Yersinia pestis Nepal516, complete genome75.0613 %Subject ←→ Query30.0006
NC_008149:3648139Yersinia pestis Nepal516, complete genome96.7402 %Subject ←→ Query29.4565
NC_008149:1221637Yersinia pestis Nepal516, complete genome76.97 %Subject ←→ Query30.5812
NC_006155:1567306Yersinia pseudotuberculosis IP 32953, complete genome76.0018 %Subject ←→ Query33.2342
NC_010634:3269010*Yersinia pseudotuberculosis PB1/+, complete genome76.5962 %Subject ←→ Query28.5333
NC_010634:2960000Yersinia pseudotuberculosis PB1/+, complete genome75.0858 %Subject ←→ Query31.2014
NC_010634:1565788Yersinia pseudotuberculosis PB1/+, complete genome76.2102 %Subject ←→ Query33.0113
NC_010465:804249Yersinia pseudotuberculosis YPIII, complete genome92.454 %Subject ←→ Query29.499